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CBR-470-1 is an Inhibitor of the glycolytic enzyme PGK1 that induces Nrf2 activity. PGK1 inhibition results in acculumation of methylglyoxalyl (MGO), a toxic, reactive metabolite removed by other enzymes. The accumulated MGO then irreversibly reacts with Keap1 forming inactive Keap1 dimers, resulting in accumulation of Nrf2.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jeyun Jo et al.
Bioorganic chemistry, 108, 104614-104614 (2021-01-29)
The transcription factor NRF2 controls resistance to oxidative insult and is thus a key therapeutic target for treating a number of disease states associated with oxidative stress and aging. We previously reported CBR-470-1, a bis-sulfone which activates NRF2 by increasing
Jinyu Zheng et al.
Aging, 12(13), 13388-13399 (2020-07-11)
The neurotoxin MPP+ (1-methyl-4-phenylpyridinium ion) disrupts mitochondrial function leading to oxidative stress and neuronal death. Here we examine whether activation of the Keap1-Nrf2 cascade can protect SH-SY5Y neuroblastoma cells from MPP+-induced cytotoxicity. Treatment of SH-SY5Y cells with CBR-470-1, an inhibitor
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