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SML2940

Sigma-Aldrich

ML417

≥98% (HPLC)

别名:

(1H-Indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone, Methanone, 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-

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About This Item

经验公式（希尔记法）:
C22H25N3O3
CAS号:
1386162-69-1
分子量:
379.45
MDL编号:
MFCD32693923
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

N2(CCN(CC2)C(=O)c3[nH]c4c(c3)cccc4)CCOc1ccc(cc1)OC

InChI key

HAZPAMUWUHDPDA-UHFFFAOYSA-N

生化/生理作用

ML417 is a blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R) with very limited cross-reactivity at other GPCRs. ML417 potently induces G-protein activation, D3R-mediated b-arrestin translocation and pERK phosphorylation. It does not activate other dopamine receptors. ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA induced cell death.
blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Amy E Moritz et al.
Journal of medicinal chemistry, 63(10), 5526-5567 (2020-04-29)
To identify novel D3 dopamine receptor (D3R) agonists, we conducted a high-throughput screen using a β-arrestin recruitment assay. Counterscreening of the hit compounds provided an assessment of their selectivity, efficacy, and potency. The most promising scaffold was optimized through medicinal

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