SML2912
UNC4976 Trifluoroacetate
≥95% (HPLC)
别名:
Methyl N6-(bicyclo[2.2.1]heptan-2-yl)-N2-(4-(tert-butyl)benzoyl)-L-phenylalanyl-L-alanyl-L-leucyl-N6-methyl-L-lysyl-L-serinate trifluoroacetate
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C47H70N6O8 · xC2HF3O2
分子量:
847.09 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
质量水平
方案
≥95% (HPLC)
表单
film
颜色
white to beige
运输
wet ice
储存温度
−20°C
SMILES字符串
N([C@@H](CO)C(=O)OC)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c4ccc(cc4)C(C)(C)C)Cc3ccccc3)C)CC(C)C)CCCCN(C1C2CC(C1)CC2)C
InChI key
UKWNWTBRKZUHGX-GKUWNYOMSA-N
生化/生理作用
UNC4976 is a cell penetrant and potent positive allosteric modulator (PAM) of CBX7 chromodomain of polycomb repressive complex 1 that enhances CBX7 chromodomain affinity for nucleic acids. UNC4976 substantially potentiates the expression of polycomb target genes.
cell penetrant and potent positive allosteric modulator (PAM) of CBX7 chromodomain
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Kelsey N Lamb et al.
Cell chemical biology, 26(10), 1365-1379 (2019-08-20)
Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM) peptidomimetic, UNC4976, of nucleic acid binding by CBX7, a chromodomain methyl-lysine reader
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持