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Merck
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SML2823

Sigma-Aldrich

GT949

≥98% (HPLC)

别名:

3-[(4-Cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-2(1H)-quinolinone, GT 949, GT-949

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About This Item

经验公式（希尔记法）:
C30H37N7O2
CAS号:
460330-27-2
分子量:
527.66
MDL號碼:
MFCD03129031
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C1C(C(C2=NN=NN2CCC3=CC=CC=C3)N4CCN(CC4)C5CCCCC5)=CC6=CC(OC)=CC=C6N1

生化／生理作用

GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC50 = 0.26 nM; COS-7 EAAT2 transfectant), but not EAAT1 or EAAT3. GT949 enhances glutamate uptake of cultured rat astrocytes (EC50 = 1 nM, Emax = 158%) with no potency toward human serotonin (SERT), noradrenaline (NET) and dopamine (DAT) transporters, nor NMDA receptors (murine primary cortical neurons).
Potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2, but not EAAT1, EAAT3, NMDAR, SERT, NET, or DAT.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000103149
0000103150
0000099662

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Sandhya Kortagere et al.
ACS chemical neuroscience, 9(3), 522-534 (2017-11-16)
Dysfunction of excitatory amino acid transporters (EAATs) has been implicated in the pathogenesis of various neurological disorders, such as stroke, brain trauma, epilepsy, and neurodegenerative diseases, among others. EAAT2 is the main subtype responsible for glutamate clearance in the brain
Romulo Martelli Falcucci et al.
ACS chemical neuroscience, 10(8), 3437-3453 (2019-07-02)
Dysfunction of excitatory amino acid transporters (EAATs) has been implicated in the pathogenesis of various neurological disorders, such as stroke, brain trauma, epilepsy, and several neurodegenerative disorders. EAAT2 is the main transporter subtype responsible for glutamate clearance in the brain
Rong-Wei Zhang et al.
Cell reports, 27(10), 2871-2880 (2019-06-06)
Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by amacrine cells and bipolar cells, the behavior and

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