化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C1C2=C(N=C(N1)N[C@H](C3=CC=C(C=C3)Cl)C)N(C4CCCC4)N=C2
生化／生理作用
(S)-C33 [C33(S)] is a potent and selective phosphodiesterase-9A (PDE9A) inhibitor that upregulates cGMP signaling. (S)-C33 protects against cardiac hypertrophy and postpones the transition to heart failure in rat models.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Manna Huang et al.
Molecular pharmacology, 88(5), 836-845 (2015-09-01)
Phosphodiesterase-9 (PDE9) inhibitors have been studied as potential therapeutics for treatment of central nervous system diseases and diabetes. Here, we report the discovery of a new category of PDE9 inhibitors by rational design on the basis of the crystal structures.
Pan-Xia Wang et al.
Acta pharmacologica Sinica, 38(9), 1257-1268 (2017-06-27)
Phosphodiesterase-9A (PDE9A) expression is upregulated during cardiac hypertrophy and heart failure. Accumulating evidence suggests that PDE9A might be a promising therapeutic target for heart diseases. The present study sought to investigate the effects and underlying mechanisms of C33(S), a novel
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