SML2560

OB-1

≥98% (HPLC)

• 别名: Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
• 经验公式（希尔记法）: C₂₁H₁₇N₃O₆
• CAS号: 300803-69-4
• 分子量: 407.38
• MDL编号: MFCD01462999
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to very dark brown
• 溶解性: DMSO: 2 mg/mL, clear
• 储存温度: 2-8°C
• SMILES字符串: [N+](=O)([O-])c1nc[n](c1Oc2cc3c([o]c(c3C(=O)OCC)c4ccccc4)cc2)C
• InChI key: UJHGRDVYTTVJFD-UHFFFAOYSA-N

说明

生化/生理作用

Inhibitor of Stomatin-like protein-3 (STOML3) oligomerization

OB-1 is an inhibitor of the oligomerization of Stomatin-like protein-3 (STOML3), which is a modulator of the mechanosensitive ion channel Piezo2. STOML3 requires oligomerization for its role as an endogenous regulator of the sensitivity of mechanosensitive Piezo ion channels in sensory neurons. By inhibiting this activity, OB-1 has been shown to reduce touch-evoked pain behavior in two mouse models of neuropathic pain.

安全信息

• 储存分类代码: 13 - Non Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable