SML2490

APC366 trifluoroacetate

≥97% (HPLC)

• 别名: APC 366 trifluoroacetate, N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide, N2-[(1-Hydroxy-2-naphthalenyl)carbonyl]-L-arginyl-L-prolinamide trifluoroacetate
• 经验公式（希尔记法）: C₂₂H₂₈N₆O₄ · xC₂HF₃O₂
• CAS号: 158921-85-8
• 分子量: 440.50 (free base basis)
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥97% (HPLC)
• 表单: lyophilized powder
• 颜色: white to off-white
• 运输: wet ice
• 储存温度: −20°C
• SMILES字符串: FC(F)(C(O)=O)F.NC(NCCC[C@@H](C(N1CCC[C@H]1C(N)=O)=O)NC(C2=C(O)C3=CC=CC=C3C=C2)=O)=N
• InChI: 1S/C22H28N6O4/c23-19(30)17-8-4-12-28(17)21(32)16(7-3-11-26-22(24)25)27-20(31)15-10-9-13-5-1-2-6-14(13)18(15)29/h1-2,5-6,9-10,16-17,29H,3-4,7-8,11-12H2,(H2,23,30)(H,27,31)(H4,24,25,26)/t16-,17-/m0/s1
• InChI key: SKYWIMYOGAWOMB-IRXDYDNUSA-N

说明

生化/生理作用

APC366 is a selective inhibitor of mast cell tryptase, which is involved with allergenic response. It thereby also inhibits protease-activated receptor PAR2, a G-protein-coupled receptor that is activated by mast cell tryptase. Tryptase has been proposed to be involved in fibrosis, joint inflammation and also in promoting breast cancer angiogenesis, all of which APC366 inhibited.

Mast cell tryptase inhibitor