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Merck
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SML2390

Sigma-Aldrich

JNS 1-40

≥95% (HPLC)

别名:

N-benzyl-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide

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About This Item

经验公式（希尔记法）:
C17H16ClNO3
CAS号:
2241773-03-3
分子量:
317.77
UNSPSC代码:
12352200

方案

≥95% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C(CCl)N(CC1=CC=CC=C1)C2=CC3=C(OCCO3)C=C2

InChI

1S/C17H16ClNO3/c18-11-17(20)19(12-13-4-2-1-3-5-13)14-6-7-15-16(10-14)22-9-8-21-15/h1-7,10H,8-9,11-12H2

InChI key

POYZNHCCXQEULA-UHFFFAOYSA-N

生化/生理作用

JNS 1-40 is a potent and selective cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the tumor-suppressor protein phosphatase 2A (PP2A) that activate PP2A in vitro and in vivo. JNS 1-40 targets C377 of PPP2R1A and inhibits breast cancer proliferation, and in vivo tumor growth.
cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the PP2A that activate PP2A

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000061192
0000061193
0000047255

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Elizabeth A Grossman et al.
Cell chemical biology, 24(11), 1368-1376 (2017-09-19)
Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as drugs. Identifying druggable hotspots targeted by covalently acting anti-cancer natural products can enable pharmacological interrogation of these sites

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