SML2164

Bepristat 1a

≥98% (HPLC)

• 别名: 1-[(3-Chloro-4-hydroxyphenyl)methyl]-N-ethyl-N-methyl-4-(2-phenoxyethyl)-4-piperidinecarboxamide
• 经验公式（希尔记法）: C₂₄H₃₁ClN₂O₃
• CAS号: 1642375-66-3
• 分子量: 430.97
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to light brown
• 溶解性: DMSO: 2 mg/mL, clear
• 储存温度: 2-8°C
• SMILES字符串: ClC1=C(O)C=CC(CN2CCC(C(N(CC)C)=O)(CCOC3=CC=CC=C3)CC2)=C1
• InChI key: AYJKPBTXOIHUFT-UHFFFAOYSA-N

说明

生化/生理作用

Bepristat 1a is a selective reversible inhibitor of protein disulfide isomerase (PDI), an enzyme in the endoplasmic reticulum that catalyzes disulfide bond breakage and reformation to catalyze protein folding. Unlike most PDI inhibitors, Bepristat 1a binds at the substrate-binding site, rather than the catalytic site. It blocked PDI activity with an IC50 value of 700 nM. PDI is up-regulated in several cancers, has been implicated in neurodegenerative processes, and plays an important role in thrombus formation. Bepristat 1a potently inhibited platelet aggregation and thrombus formation in vivo.

Selective reversible inhibitor of protein disulfide isomerase (PDI)

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable