SML2123

BRF110

≥98% (HPLC)

• 别名: 4-[Methyl[2-phenyl-5-(2-propen-1-yl)-6-(trifluoromethyl)-4-pyrimidinyl]amino]benzoic acid
• 经验公式（希尔记法）: C₂₂H₁₈F₃N₃O₂
• CAS号: 2095489-35-1
• 分子量: 413.39
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(C1=CC=C(N(C2=NC(C3=CC=CC=C3)=NC(C(F)(F)F)=C2CC=C)C)C=C1)O

说明

生化／生理作用

BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable