所有图片(1)
About This Item
经验公式（希尔记法）:
C22H28N4O6 · 2HCl
CAS号:
分子量:
517.40
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
blue
溶解性
H2O: 3 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
O=C1C2=C(C(NCC[N+](C)([O-])C)=CC=C2NCC[N+]([O-])(C)C)C(C3=C(O)C=CC(O)=C31)=O.[H]Cl.[H]Cl
InChI
1S/C22H28N4O6.2ClH/c1-25(2,31)11-9-23-13-5-6-14(24-10-12-26(3,4)32)18-17(13)21(29)19-15(27)7-8-16(28)20(19)22(18)30;;/h5-8,23-24,27-28H,9-12H2,1-4H3;2*1H
InChI key
SBWCPHUXRZRTDP-UHFFFAOYSA-N
应用
Banoxantrone Dihydrochloride作为有机配体用于自组装金属-有机配位纳米粒子(Cu–OCNP/Lap)的合成。它也被用于制备超分子功能化氧化石墨烯，用于癌症的缺氧活化化疗。
生化/生理作用
Banoxantrone Dihydrochloride可增强辐射所致的抗肿瘤作用。
巴诺蒽醌（AQ4N）是拓扑异构酶II抑制剂AQ4（生物还原性AQ4前体）的一种低氧激活前药。
拓扑异构酶II抑制剂AQ4的低氧激活前药
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Olivier Trédan et al.
Cancer research, 69(3), 940-947 (2009-01-30)
Hypoxic tumor cells are likely to be resistant to conventional chemotherapy, in large part because many anticancer drugs are unable to penetrate into poorly oxygenated tumor tissue. Here, we used quantitative immunofluorescence to study the distribution of mitoxantrone and AQ4N
O P Friery et al.
British journal of cancer, 82(8), 1469-1473 (2000-04-26)
The ability of the bioreductive drugs AQ4N and tirapazamine to enhance the anti-tumour effect of cyclophosphamide was assessed in three murine tumour models. In male BDF mice implanted with the T50/80 mammary carcinoma, AQ4N (50-150 mg kg(-1)) in combination with
Qi Zhang et al.
Scientific reports, 12(1), 6294-6294 (2022-04-21)
Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane
Yuling He et al.
Biomaterials, 275, 120962-120962 (2021-06-22)
Chemodynamic therapy (CDT) is an ideal therapeutic modality with endogenous H2O2 as stimulus. Most intracellular H2O2 supplement strategies for improving CDT efficiency are strongly rely on oxygen participation, and the hypoxia tumor microenvironment impairs their performance. Here we develop a
Yuan-Fu Ding et al.
Biomaterials science, 9(10), 3804-3813 (2021-04-22)
Nano-graphene oxide (NGO) has attracted increasing attention as an advanced drug delivery system. However, the current surface functionalization and drug-loading of NGO either rely on π-π stacking that is limited to aromatic molecules, or covalent conjugation that requires tedious synthesis.
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