SML1801

CeMMEC13

≥98% (HPLC)

• 别名: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide
• 经验公式（希尔记法）: C₁₉H₁₆N₂O₄
• CAS号: 1790895-25-8
• 分子量: 336.34
• UNSPSC代码: 12352202
• PubChem化学物质编号: 329826074
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 储存温度: 2-8°C
• SMILES字符串: CN(C1=C2C=CC=C1)C(C=C2C(NC3=CC=C4C(OCCO4)=C3)=O)=O

说明

生化/生理作用

CeMMEC13 is a potent inhibitor of the second bromodomain of the transcription initiation factor TAF1 with an an IC₅₀ value of 2.1 μM and with minimal inhibition of BRD4, BRD9, CREBBP, or EP300. CeMMEC13 was found to synergize with BRD4 inhibitor (S)-JQ1 to arrest the proliferation of leukemia cell line THP1 and lung adenocarcinoma cell line H23.

CeMMEC13 is a potent inhibitor of the second bromodomain of the transcription initiation factor TAF1.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302
• 预防措施声明: P301 + P312 + P330
• 危险分类: Acute Tox. 4 Oral
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable