SML1711

TNCA

≥98% (HPLC)

• 别名: (3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, Lycoperodine-1
• 经验公式（希尔记法）: C₁₂H₁₂N₂O₂
• CAS号: 42438-90-4
• 分子量: 216.24
• MDL编号: MFCD00272641
• UNSPSC代码: 12352200
• PubChem化学物质编号: 329826033
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 旋光性: [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
• 颜色: white to beige
• 溶解性: 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
• 储存温度: −20°C
• SMILES字符串: O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
• InChI: 1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
• InChI key: FSNCEEGOMTYXKY-JTQLQIEISA-N

说明

生化/生理作用

TNCA is a tryptophan derivative that binds the parathyroid Ca²⁺-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity.

TNCA is a tryptophan derivative that binds the parathyroid Ca²⁺-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable