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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
OC(C)(C)C1=C(C(O)=O)N(CC2=CC=C(C3=C(C4=NNN=N4)C=CC=C3)C=C2)C(CCC)=N1
InChI
1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)
InChI 密鑰
VTRAEEWXHOVJFV-UHFFFAOYSA-N
基因資訊
human ... AGTR1(185)
應用
奥美沙坦已用作血管紧张素 II 受体 1（AT1） 的受体抑制剂，用于研究血管紧张素 II 1 型受体相互作用在调节血管紧张素 II 依赖性高血压中肾传入小动脉的作用。
生化／生理作用
奥美沙坦具有抗炎和抗氧化应激特性。它保护神经元细胞免于低聚淀粉样蛋白β（Aβ）诱导的细胞衰老。
奥美沙坦是一种血管紧张素 ⅡⅠ 型受体阻滞剂。奥美沙坦是降压药奥美沙坦酯的活性形式。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Albuminuria is a predictor of disease progression in patients with chronic kidney disease (CKD). However, the ability of proteinuria parameters measured at various time periods to predict renal outcomes is unclear. This observational cohort study included 165 non-diabetic hypertensive CKD
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Regulatory toxicology and pharmacology : RTP, 82, 20-31 (2016-11-07)
Poor aqueous solubility and unfavourable de-esterification of olmesartan medoxomil (a selective angiotensin II receptor blocker), results in low oral bioavailability of less than 26%. Improvement of oral bioavailability with prolonged pharmacodynamics activity of olmesartan in Wistar rats had been approached
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