SML1215

Cuspin-1

≥98% (HPLC)

• 别名: (5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
• 经验公式（希尔记法）: C₁₃H₁₀BrNO
• CAS号: 337932-29-3
• 分子量: 276.13
• MDL號碼: MFCD00452965
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825725
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 5 mg/mL, clear (warmed)
• 儲存溫度: room temp
• SMILES 字串: CC(C=C1)=CC=C1C(C2=CC(Br)=CN=C2)=O
• InChI: 1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3
• InChI 密鑰: AJZRSLVRFSCCIL-UHFFFAOYSA-N

说明

生化／生理作用

Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN), necessary for survival of motor neurons. SMN is decreased in the neurodegenerative disease Spinal Muscular Atrophy (SMA), an autosomal recessive disease caused by a genetic defect in the SMN1 gene. SMA is the second leading cause of neuromuscular disease, after Duchenne muscular dystrophy. Cuspin-1 increased SMN levels by 50-100% in SMA patient fibroblast cells accompanied by an increase in the phosphorylation of Erk, suggesting inbvolvement of the Ras-Raf-MEK cascade.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3