SML1000

RU-SKI 43 maleate

≥98% (HPLC)

• 别名: 1-[6,7-Dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-ethanone maleate, 2-((2-Methylbutyl)amino)-1-(4-((m-tolyloxy)methyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone maleic acid salt
• 经验公式（希尔记法）: C₂₂H₃₀N₂O₂S · C₄H₄O₄
• CAS号: 1043797-53-0
• 分子量: 502.62
• UNSPSC代码: 51111800
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 储存温度: room temp
• InChI: 1S/C22H30N2O2S/c1-4-16(2)13-23-14-22(25)24-10-8-21-19(9-11-27-21)20(24)15-26-18-7-5-6-17(3)12-18/h5-7,9,11-12,16,20,23H,4,8,10,13-15H2,1-3H3
• InChI key: AEENEMOEBJOKGN-UHFFFAOYSA-N

说明

生化/生理作用

RU-SKI 43 is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat) with an IC₅₀ of 850 nM. RU-SKI 43 is the first small molecule found that inhibits the activity of Hedgehog acyltransferase (Hhat) and inhibits palmitoylation of Shh by endogenous Hhat in vitro and in cells. Most inhibitors of hedgehog signaling act downstream, inhibiting Smo or Gli components of the Shh pathway. The upstream activity of RU-SKI 43 directly on palmitoylation of the Shh ligand is unique.

RU-SKI 43 is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat).

安全信息

• 储存分类代码: 13 - Non Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable