推荐产品
产品名称
ML-SA1, ≥95% (HPLC)
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
N3(C(=O)c4c(cccc4)C3=O)CC(=O)N1C(CC(c2c1cccc2)C)(C)C
InChI
1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
InChI key
KDDHBJICVBONAX-UHFFFAOYSA-N
应用
ML-SA1 已被用作瞬时受体电位阳离子通道粘脂肽 1 (TRPML1/ML1) 激动剂。
生化/生理作用
ML-SA1 是溶酶体粘脂素瞬时受体电位通道 (TRPML) 1、2、3 的一种强效选择性细胞渗透性激动剂，可显著增加 HEK293 细胞稳定或短暂表达突变型 TRPML1 通道 ML1-4A 中的 [Ca 2+] cyt。
ML-SA1 是溶酶体粘脂素瞬时受体电位通道 (TRPML) 1、2、3 的强效选择性细胞渗透性激动剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle.
Sahoo N, et al.
Developmental Cell, 41(3), 262-273 (2017)
Dengqin Zhong et al.
Nature communications, 14(1), 3997-3997 (2023-07-07)
Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose. However, the roles of lysosomes in U decorporation and detoxification remain to be elucidated. Mucolipin
Hongyan Yu et al.
British journal of cancer, 125(10), 1420-1431 (2021-09-23)
Prostate cancer (Pca) is the most common cancer type among males worldwide. Dysregulation of Ca2+ signaling plays important roles during Pca progression. However, there is lack of information about the role of endolysosomal Ca2+ -permeable channels in Pca progression. The
Simona Ida Scorza et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Lysosomes are acidic Ca2+ storage organelles that actively generate local Ca2+ signaling events to regulate a plethora of cell functions. Here, we characterized lysosomal Ca2+ signals in mouse renal collecting duct (CD) cells and we assessed their putative role in
Lalit Pukhrambam Singh et al.
Diseases (Basel, Switzerland), 9(4) (2021-12-24)
Chronic hyperglycemia-induced thioredoxin-interacting protein (TXNIP) expression, associated oxidative/nitrosative stress (ROS/RNS), and mitochondrial dysfunction play critical roles in the etiology of diabetic retinopathy (DR). However, there is no effective drug treatment to prevent or slow down the progression of DR. The
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