SML0555

ML289

≥98% (HPLC)

• 别名: VU0463597, [(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone
• 经验公式（希尔记法）: C₂₂H₂₃NO₃
• CAS号: 1382481-79-9
• 分子量: 349.42
• UNSPSC代码: 12352200

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear
• 储存温度: 2-8°C
• InChI: 1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
• InChI key: VSLWUPHHCFQTDB-LJQANCHMSA-N

说明

生化/生理作用

ML289 (VU0463597) is a potent, selective and centrally penetrant negative allosteric modifier (NAM) of metabotropic glutamate receptor 3 (mGlu3). ML289 is >15-fold selective vs mGlu2 with an IC₅₀ value of 0.66 μM.

ML289 is a potent, selective and centrally penetrant negative allosteric modifier (NAM) of metabotropic glutamate receptor 3 (mGlu3).

特点和优势

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H315,H319,H335
• 预防措施声明: P261 - P305 + P351 + P338
• 危险分类: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 储存分类代码: 13 - Non Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable