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Merck
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文件

SML0482

Sigma-Aldrich

3CAI

≥95% (HPLC)

别名:

2-Chloro-1-(1H-indol-3-yl)ethanone, 3-Chloroacetyl-indole, Chloromethyl indol-3-yl ketone

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About This Item

经验公式（希尔记法）:
C10H8ClNO
CAS号:
28755-03-5
分子量:
193.63
MDL號碼:
MFCD00464796
分類程式碼代碼:
12352200
PubChem物質ID:
329825433
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

儲存條件

desiccated
protect from light

顏色

yellow to brown

溶解度

DMSO: 5 mg/mL, clear

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

O=C(CCl)C1=CNC2=C1C=CC=C2

InChI

1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2

InChI 密鑰

LLZQFAXTCYDVTR-UHFFFAOYSA-N

生化／生理作用

3CAI is an orally active, potent and specific allosteric inhibitor of Akt1 and Akt2 that directly binds to Ak1 and Akt2 in an ATP noncompetitive manner.

特點和優勢

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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Ji-Eun Kim et al.
Cell death & disease, 9(5), 546-546 (2018-05-12)
Recently, we have reported that heat shock protein B1 (HSPB1) and purinergic receptor P2X7 (P2RX7) are involved in astroglial autophagy (clasmatodendrosis), following status epilepticus (SE). However, the underlying mechanisms of astroglial autophagy have not been completely established. In the present
[Photometric determination of 3-chloroacetyl indole in the air].
E I Kosterina et al.
Gigiena i sanitariia, (2)(2), 48-49 (1988-02-01)

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