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化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL (clear solution, warmed)
儲存溫度
room temp
SMILES 字串
BrC1C(Br)C(Br)C(Br)C(Br)C1Br
InChI
1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChI 密鑰
QFQZKISCBJKVHI-UHFFFAOYSA-N
生化／生理作用
1,2,3,4,5,6-hexabromocyclohexane binds directly to a pocket within the kinase domain of JAK2 and inhibits autophosphorylation. The compound also blocks growth hormone induced JAK2 autophosphorylation without affecting EFGR autophosphorylation.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Kotaro Horiguchi et al.
Cell and tissue research, 364(2), 395-404 (2015-11-18)
Secretion of hormones by the anterior pituitary gland can be stimulated or inhibited by paracrine factors that are produced during inflammatory reactions. The inflammation cytokine interferon-gamma (IFN-γ) is known to inhibit corticotropin-releasing factor (CRF)-stimulated adrenocorticotropin (ACTH) release but its signaling
Jeffrey D Kittilson et al.
Frontiers in endocrinology, 2, 30-30 (2011-01-01)
Previously, we found that the teleost fish, rainbow trout, possesses two growth hormone receptor (GHR) subtypes that display distinct ligand-binding and agonist-induced regulation features. In this study, we used Chinese hamster ovary-K1 cells stably transfected individually with the two trout
Anshu Agrawal et al.
Aging, 4(9), 648-659 (2012-10-16)
Advancing age leads to significant decline in immune functions. IL-21 is produced primarily by T follicular helper (Tfh) cells and is required for effective immune cell functions. Here we compared the induction of IL-21 in aged and young subjects. Our
Xue Jiang et al.
Frontiers in endocrinology, 11, 20-20 (2020-02-23)
In mammals, local production of tumor necrosis factor α (TNFα) inhibits growth hormone (GH)-induced IGF-I expression at tissue level and contributes to GH resistance caused by sepsis/endotoxemia and inflammation. Although the loss of GH responsiveness can be mediated by a
Shirley C Mills et al.
Cellular signalling, 28(4), 316-324 (2016-01-26)
Chemotaxis or directed cell migration is mediated by signalling events initiated by binding of chemokines to their cognate receptors and the activation of a complex signalling cascade. The molecular signalling pathways involved in cell migration are important to understand cancer
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