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Merck
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SML0381

Sigma-Aldrich

ALLO-1

≥98% (HPLC)

别名:

3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-Imidazolidinedione

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About This Item

经验公式（希尔记法）:
C17H15ClN2O2
CAS号:
37468-32-9
分子量:
314.77
MDL编号:
MFCD19441284
UNSPSC代码:
51111800
PubChem化学物质编号:
329825381

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: >10 mg/mL

储存温度

2-8°C

SMILES字符串

CC1N(Cc2ccccc2)C(=O)N(C1=O)c3ccc(Cl)cc3

InChI

1S/C17H15ClN2O2/c1-12-16(21)20(15-9-7-14(18)8-10-15)17(22)19(12)11-13-5-3-2-4-6-13/h2-10,12H,11H2,1H3

InChI key

GHAJNZREWTZYQJ-UHFFFAOYSA-N

生化/生理作用

ALLO-1 is a Smoothened (Smo) antagonist that inhibits both wild-type and mutant Smo, including D473H SMO mutant. ALLO-1 binds to a different domain of Smo than other known Smo ligands.
ALLO-1 is a Smoothened (Smo) antagonist that inhibits both wild-type and mutant Smo.

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
062M4616V

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Miyuki Sato et al.
Nature cell biology, 20(1), 81-91 (2017-12-20)
In Caenorhabditis elegans embryos, paternally provided organelles, including mitochondria, are eliminated by a process of selective autophagy called allophagy, the mechanism by which mitochondrial DNA is inherited maternally. However, it remains unclear how paternal organelles are recognized and targeted for

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