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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
light yellow to yellow-green
溶解性
DMSO: ≥5 mg/mL
储存温度
2-8°C
SMILES字符串
CC(CN(C)C)CN1c2ccccc2Sc3ccc(cc13)C#N
InChI
1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
InChI key
SLFGIOIONGJGRT-UHFFFAOYSA-N
应用
Cyamemazine has been used as an internal standard and antipsychotic drug to spike plasma samples in mass spectrometry studies. It has also been used as an analytical standard in gas chromatography-tandem mass spectroscopic (GC-MS/MS) analysis.
生化/生理作用
Cyamemazine belongs to the class of phenothiazine drugs. It is known to treat severe depression, schizophrenia and bipolar disorder.
Cyamemazine is a potent antagonist of 5-HT2C and 5-HT3 receptors with antipsychotic and anxiolytic properties.
Cyamemazine is a potent antagonist of 5-HT2C and 5-HT3 receptors.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Cathy M Jacobs et al.
Analytical and bioanalytical chemistry, 413(6), 1729-1737 (2021-02-01)
Volumetric absorptive microsampling (VAMS), an emerging microsampling technique, is expected to overcome some disadvantages of dried blood spots such as volume inaccuracy and influence of hematocrit (HT). This study aimed to develop and evaluate a VAMS-based strategy for quantification of
William Crumb et al.
European journal of pharmacology, 532(3), 270-278 (2006-02-24)
The antipsychotic and anxiolytic phenothiazine, cyamemazine, was investigated for its effects on the hERG (human ether-à-go-go related gene) channel expressed in HEK 293 cells and on native INa, ICa, Ito, Isus, or IK1 of human atrial myocytes. Moreover, cyamemazine and
Marjorie Chèze et al.
Forensic science international, 196(1-3), 14-17 (2010-02-02)
The authors present 3 cases that demonstrate a return to DFC following periods of inactivity. The offences occurred in Paris and its suburbs and in each of the cases there were two distinct periods of activity by the offenders with
Multi-trajectories of antidepressant and antipsychotic use: a 11-year naturalistic study in a community-based sample
<BIG>Verdoux H, et al.</BIG>
Acta Psychiatrica Scandinavica (2019)
Amine Benyamina et al.
European journal of pharmacology, 578(2-3), 142-147 (2007-10-16)
Animal and human pharmacological studies indicate that the antipsychotic action of cyamemazine results from blockade of dopamine D(2) receptors, its anxiolytic properties from serotonin 5-HT(2C) receptor antagonism and the low incidence of extrapyramidal side effects from a potent 5-HT(2A) receptor
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