SML0224
HI-6
≥98% (HPLC)
别名:
1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium chloride, 4-Carbamoyl-1-[[[2-[(hydroxyimino)methyl]pyridinium-1-yl]methoxy]methyl]pyridinium dichloride, Asoxime chloride, HI 6, HI 6 chloride, HJ 6, Transant
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所有图片(1)
About This Item
经验公式（希尔记法）:
C14H16N4O3 · 2Cl
CAS号:
分子量:
359.21
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
H2O: 15 mg/mL (clear solution)
运输
wet ice
储存温度
−20°C
SMILES字符串
[Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1
InChI
1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H
InChI key
QELSIJXWEROXOE-UHFFFAOYSA-N
一般描述
HI-6 functions as an antidote for treating intoxication caused by nerve agents. It acts as a potent drug in radiation protection and suppresses oxidative stress. HI-6 prevents the toxicity of the antineoplastic drug irinotecan.
生化/生理作用
HI-6 is an efficient oxime cholinesterase reactivator that is used as an antidote for organophosphates (Ops) exposure.
HI-6 is an efficient oxime cholinesterase reactivator.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jiri Kassa et al.
Basic & clinical pharmacology & toxicology, 110(4), 322-326 (2011-10-11)
The ability of three newly developed reversible inhibitors of acetylcholinesterase (AChE) (K298, K344 and K474) and currently available carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was compared. Neither
Miriam Dadparvar et al.
Toxicology letters, 206(1), 60-66 (2011-07-06)
The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes. However, the blood-brain barrier (BBB) restricts the rapid transport of these drugs from the blood into the brain in therapeutically
Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model
Pohanka M, et al.
Neuro Endocrinology Letters, 31(2), 62-62 null
Reinhard Bogan et al.
Drug testing and analysis, 4(3-4), 199-207 (2012-03-01)
As reactivators of inhibited acetylcholinesterase, oximes are essential antidotes in poisoning by organophosphorus compounds. Due to its superior efficacy in cases of soman, cyclosarin, and sarin poisoning, the oxime HI-6 represents a promising option for an active pharmaceutical ingredient (API)
Miroslav Pohanka et al.
Drug and chemical toxicology, 34(3), 255-260 (2011-06-09)
Oxime reactivator HI-6 (asoxime, in some sources) is a potent antidote suitable for treatment of intoxication by nerve agents. Despite the fact that HI-6 is considered for practical application in emergency situations, the impact of HI-6 on patients' bodies has
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