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Merck
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文件

SMB00424

Sigma-Aldrich

桔梗皂苷D

≥98% (HPLC)

别名:

3β-(β-D-吡喃葡萄糖基氧基)-2β,16α,23,24-四羟基-O-D-apio-β-D-呋喃基-(1→3)-O-β-D-吡喃木糖基-(1→4)-O-6-脱氧-齐墩果-12-烯-28-酸

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About This Item

经验公式（希尔记法）:
C57H92O28
CAS号:
58479-68-8
分子量:
1225.32
分類程式碼代碼:
12352205
PubChem物質ID:
329825010
NACRES:
NA.25

品質等級

200

化驗

≥98% (HPLC)

形狀

powder

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

2-8°C

SMILES 字串

O[C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(CO)(CO)[C@]3([H])CC[C@@]4(C)[C@]5(C)C[C@@H](O)[C@@]6(C(O[C@H]7[C@H](O[C@@H]8O[C@@H](C)[C@H](O[C@H]9[C@H](O)[C@@H](O[C@@H]%10OC[C@@](CO)(O)[C@H]%10O)[C@H](O)CO9)[C@@H](O)[C@H]8O)[C@@H](O)[C@@H](O

InChI

1S/C57H92O28/c1-23-40(81-45-39(72)41(30(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)29(63)17-77-48(42)85-50(74)57-12-11-51(2,3)14-27(57)24-7-9-52(4)26-13-28(62)44(84-47-37(70)35(68)34(67)31(16-58)80-47)55(19-59,20-60)25(26)8-10-54(52,6)53(24,5)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25+,26-,27-,28-,29-,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48?,49-,52+,53+,54+,56+,57+/m0/s1

InChI 密鑰

RJDYKSRQTBCKLC-XTIQGCOGSA-N

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相关类别

一般說明

桔梗皂苷D (platycodin D)是从桔梗根(Platycodonis Radix)中提取的一种三萜皂苷。

應用

桔梗皂苷D已用于：
  • 使用卵清白蛋白(OVA)诱导的过敏性哮喘小鼠模型，检测其对嗜酸性气道炎症和2型助性T细胞(Th2)信号通路的抗炎和抑制作用
  • 在体内和体外研究中，检测其激活褐色脂肪组织的抗肥胖作用
  • 检测其作为鸡传染性支气管炎(IB)疫苗佐剂的效能

生化／生理作用

桔梗皂苷D具有较强的抗癌性，对体外和体内来源的多种肿瘤细胞株均具有细胞毒性作用。可通过上调肝X受体α(LXRα)和ATP-结合盒转运蛋白A1(ABCA1)信号传导通路，发挥对脂多糖(LPS)诱导的急性肺损伤(ALI)具有抗炎和保护功效。也对顺铂诱导(CDDP)的小鼠肾毒性具有保护作用。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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J L Gajewski et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 7(11), 1637-1645 (1989-11-01)
One hundred ninety-six patients with acute myelogenous leukemia (AML) were treated with intensive induction chemotherapy using similar daunorubicin/cytarabine/thioguanine regimens. Treatment results of 44 patients who had a documented preleukemic syndrome or cytopenia present for more than 2 months before developing
Eung Gu Lee et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 1-11 (2021-06-16)
Introduction: Bronchial asthma is a common chronic inflammatory condition of the airway tissue. Platycodin D (PLD) has antiinflammatory effects in a mouse model of allergic asthma. In this work, the anti-asthma potential of PLD was studied by investigation of its
Yefei Zhou et al.
The journal of poultry science, 57(2), 160-167 (2020-05-29)
Adjuvants are common vaccine components. Novel adjuvants may improve the protective immunity conferred by vaccines against poultry diseases. Here, a less-hemolytic saponin, platycodin D (PD), isolated from the root of Platycodon grandiflorum was investigated as a potential alternative adjuvant. PD
Tae-Won Kim et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(12), 4254-4259 (2012-05-24)
Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR
Hye-Lin Kim et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 52, 254-263 (2019-01-03)
Platycodi Radix (root of Platycodon grandiflorum) and its active compound platycodin D (PD) has been previously shown to possess anti-obesity properties, but the underlying mechanisms remain poorly understood. The present study was aimed to evaluate the anti-obese effect of PD
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