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![[Ala28]-淀粉样蛋白β 25-35 ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/images/306/938/dd9f7c72-cfca-4ea3-8e10-a7a2a7994639/640/dd9f7c72-cfca-4ea3-8e10-a7a2a7994639.jpg)
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Amino Acid Sequence
Ac-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
一般說明
淀粉样蛋白-β(Aβ）多肽是阿尔茨海默大脑特征性老年斑的主要成分。为 I型跨膜蛋白。淀粉样β蛋白前体蛋白裂解为长度为 36-43 个氨基酸的淀粉样肽。Aβ(25-35) 代表斑块形成过程中聚集的区域，是涉及神经营养和神经毒性作用的功能域。基因编码淀粉样蛋白β定位于人类 21 号染色体。乙酰化可改善体外和体内试验的稳定性。
應用
乙酰-淀粉样β 25-35蛋白25-35 已被用于制备阿尔茨海默病大鼠模型。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Effect of yizhitongxuan decoction on learning and memory ability, Gaq/11 expression and Na(+)-K(+)-ATP enzyme activity in rat models of Alzheimer's disease.
Teng J
Journal of Traditional Chinese Medicine = Chung i Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine, 34(4), 470-476 (2014)
Conformational Dynamics of Specific A? Oligomers Govern Their Ability To Replicate and Induce Neuronal Apoptosis.
Dean DN
Biochemistry, 55(15), 2238-2250 (2016)
Monomeric Amyloid Beta Peptide in Hexafluoroisopropanol Detected by Small Angle Neutron Scattering.
Zhang-Haagen B
PLoS ONE, 11(2), e0150267-e0150267 (2016)
Yili Wu et al.
Scientific reports, 6, 22460-22460 (2016-03-05)
Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neurofibrillary tangles and neuritic plaques. The expression of
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