SAB5702948

Anti-E-Cadherin Antibody, clone 2Q9Y7, Rabbit Monoclonal

• 别名: Arc-1,CD324,CDHE,ECAD,LCAM,UVO,CDH1,E-Cadherin
• UNSPSC代码: 12352203
• NACRES: NA.46

属性

• 生物来源: rabbit
• 质量水平: 100
• 物料: colorless
• 克隆: 2Q9Y7, monoclonal
• 表单: liquid
• 分子量: 135 kDa
• 种属反应性: human, rat, rat
• 浓度: 1.00 mg/mL
• 技术: immunofluorescence: 1:50 - 1:200; immunohistochemistry: 1:50 - 1:200; western blot: 1:500 - 1:1000
• 颜色: colorless
• 同位素/亚型: IgG
• 免疫原序列: PVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPR
• UniProt登记号: P12830
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: mouse ... CDH1(999)

说明

一般描述

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 700-800 of human E-Cadherin (NP_004351.1).

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

应用

WB, IHC, IF/ICC

安全信息

• 象形图: GHS07,GHS09
• 警示用语：: Warning
• 危险声明: H317,H411
• 预防措施声明: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• 危险分类: Aquatic Chronic 2 - Skin Sens. 1
• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 3