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Merck
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主要文件

SAB5702666

Sigma-Aldrich

Anti-MCM4 Antibody, clone 5N0X3, Rabbit Monoclonal

别名:

CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.46

生物来源

rabbit

质量水平

物料

colorless

克隆

5N0X3, monoclonal

表单

liquid

分子量

97 kDa

种属反应性

human, rat, rat

浓度

0.88 mg/mL

技术

western blot: 1:500 - 1:2000

颜色

colorless

同位素/亚型

IgG

免疫原序列

LHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... MCM4(4173)

一般描述

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 764-863 of human MCM4 (P33991).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

应用

WB

储存分类代码

10 - Combustible liquids

WGK

WGK 1


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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