SAB5702092

Anti-Cathepsin B Antibody, clone 6I5D7, Rabbit Monoclonal

• 别名: APPS,CPSB,Cathepsin B,CTSB
• 分類程式碼代碼: 12352203
• NACRES: NA.46

属性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 6I5D7, monoclonal
• 形狀: liquid
• 分子量: 44 kDa
• 物種活性: human
• 濃度: 0.80 mg/mL
• 技術: immunohistochemistry: 1:50 - 1:200; western blot: 1:500 - 1:2000
• 顏色: colorless
• 同型: IgG
• 免疫原序列: SDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPA
• UniProt登錄號: P07858
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CTSB(1508)

说明

一般說明

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]

免疫原

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Recombinant fusion protein containing a sequence corresponding to amino acids 27-156 of human Cathepsin B (P07858).

應用

WB, IHC

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1