SAB5700504

Anti-Phospho-NEDD4L-S448 antibody produced in rabbit

• 别名: NEDD4-2, NEDD4.2, NEDD4L, PVNH7, RSP5, hNEDD4-2
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: 96-111
• 种属反应性: rat, human, mouse
• 浓度: 1.74 mg/ml
• 技术: western blot: 1:500-1:2000
• UniProt登记号: Q96PU5
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: phosphorylation (pSer448)
• 基因信息: human ... NEDD4L(23327)

说明

一般描述

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

免疫原

A synthetic phosphorylated peptide around S448 of human NEDD4L (NP_001138439.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable