SAB4504424

Anti-phospho-HDAC8 (pSer³⁹) antibody produced in rabbit

affinity isolated antibody

• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: antigen 41 kDa
• 种属反应性: rat, human, mouse
• 浓度: ~1 mg/mL
• 技术: ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI登记号: Q9BY41
• UniProt登记号: Q9BY41
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: phosphorylation (pSer39)
• 基因信息: human ... HDAC8(55869)

说明

一般描述

HDAC8 (histone deacetylase 8) is a class I enzyme, that has 377 residues and it lies between class I and class II HDACs. This gene is located on X chromosome. It consists of a single α/β domain, in which eight parallely stranded β sheets are sandwiched between 13 α helices.

免疫原

The antiserum was produced against synthesized peptide derived from human HDAC8 around the phosphorylation site of Ser39.

Immunogen Range: 5-54

生化/生理作用

HDAC8 (histone deacetylase 8), with the help of PKA (cyclic AMP dependent protein kinase A), plays a major role in confirming the acetylation state of histones. This protein may also play an important role in acute myeloid leukemia (AML). Suppression of HDAC8 by RNA interference stops the growth of lung, colon, and cervical cancer cell lines.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable