生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 59 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pThr175+pTyr177)
基因信息
human ... MAPK15(225689)
一般描述
Mitogen-activated protein (MAP) kinase 15 (MAPK15) or extracellular signal-regulated kinase 8 (ERK8) belongs to the MAP kinase family. MAPK15 gene is located on human chromosome 8q24.3.
免疫原
The antiserum was produced against synthesized peptide derived from human ERK8 around the phosphorylation site of Thr175 and Tyr177.
Immunogen Range: 141-190
Immunogen Range: 141-190
生化/生理作用
Extracellular signal-regulated kinase 8 (ERK8)/mitogen-activated protein (MAP) kinase 15 aids in maintaining the integrity of the genome. Anaplastic thyroid carcinoma cells show high expression of MAPK15. It controls telomerase reverse transcriptase (hTERT) mRNA expression to regulate telomerase activity. It is highly essential to control the generation of reactive oxygen species. MAPK15 also plays a role in stabilizing proliferating cell nuclear antigen protein. MAPK15 might be involved in the progression of human cancer. Hence it might act as a candidate as an attractive target for cancer therapy.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Dong-Hao Jin et al.
Oncotarget, 6(24), 20190-20203 (2015-06-03)
This study was aimed at understanding the functional and clinicopathological significance of MAPK15 alteration in gastric cancer. Genome-wide copy number alterations (CNAs) were first investigated in 40 gastric cancers using Agilent aCGH-244K or aCGH-400K, and copy number gains of MAPK15
David Colecchia et al.
The Journal of biological chemistry, 293(41), 15962-15976 (2018-08-23)
Autophagy, a pathway for bulk protein degradation and removal of damaged organelles, represents one of the major responses of cells to stress, thereby exerting a strict control on their correct functioning. Consequently, this process has been involved in the pathogenesis
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