生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 95 kDa
种属反应性
rat, human, mouse
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... EEF2(1938)
一般描述
Eukaryotic elongation factor 2 (eEF2) is a cytoplasmic protein encoded by the gene mapped to human chromosome 19.
免疫原
The antiserum was produced against synthesized peptide derived from human eEF2 around the phosphorylation site of Thr56.
Immunogen Range: 31-80
Immunogen Range: 31-80
生化/生理作用
Eukaryotic elongation factor 2 (eEF2) plays a vital role in the elongation of polypeptide chain via catalyzing the translocation of the two tRNAs and the mRNA after peptidyl transfer on the 80S ribosome. eEF2 is highly expressed in various human cancers such as lung, esophageal, pancreatic, breast and prostate cancers, head and neck squamous cell carcinoma (HNSCC), glioblastoma multiforme and non-Hodgkins lymphoma (NHL). eEF2 is used as a potential marker for the diagnosis of non-small cell lung cancer (NSCLC). eEF2 activity is inhibited by the eukaryotic elongation factor-2 kinase (eEF2K), which is essential for the transmission of growth and stress signals to protein synthesis. eEF2 functions as a biochemical sensor in neuronal dendrites that links miniature synaptic events to local translational inactivation. eEF2 is also involved in nuclear deformation and aneuploidy.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Hong-Gang Sun et al.
Asian Pacific journal of cancer prevention : APJCP, 14(11), 6533-6535 (2014-01-01)
The purpose of this study was to evaluate a new type of tumor biomarker, eukaryotic elongation factor 2 (eEF2), in serum for the early diagnosis, confirmative diagnosis as well as assessment of treatment of non-small cell lung cancer (NSCLC). 130
Michael A Sutton et al.
Neuron, 55(4), 648-661 (2007-08-19)
Activity-dependent regulation of dendritic protein synthesis is critical for enduring changes in synaptic function, but how the unique features of distinct activity patterns are decoded by the dendritic translation machinery remains poorly understood. Here, we identify eukaryotic elongation factor-2 (eEF2)
R Jørgensen et al.
Biochemical Society transactions, 34(Pt 1), 1-6 (2005-10-26)
eEF2 (eukaryotic elongation factor 2) occupies an essential role in protein synthesis where it catalyses the translocation of the two tRNAs and the mRNA after peptidyl transfer on the 80 S ribosome. Recent crystal structures of eEF2 and the cryo-electron
Qi Yao et al.
The Journal of biological chemistry, 289(18), 12666-12678 (2014-03-22)
Protein-tyrosine kinase C-terminal Src kinase (Csk) was originally purified as a kinase for phosphorylating Src and other Src family kinases. The phosphorylation of a C-terminal tyrosine residue of Src family kinases suppresses their kinase activity. Therefore, most physiological studies regarding
Y Kaneda et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(10), 3158-3162 (1984-05-01)
Elongation factor 2 (EF-2), polypeptidyl -tRNA translocase, is an essential factor for protein synthesis in eukaryotic cells and Archebacteria . We isolated diphtheria toxin-resistant human primary embryo cells that contain EF-2 that cannot be ADP-ribosylated by diphtheria toxin and Pseudomonas
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