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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 110 kDa
物種活性
human, mouse, rat
濃度
~1 mg/mL
技術
ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MED24(9862)
一般說明
Mediator complex subunit 24 (MED24), also known as thyroid hormone receptor associated protein 100 (TRAP100), is encoded by the gene mapped to human chromosome 17q21.1. The protein is ubiquitously expressed in human tissues, but at high level in skeletal muscle, heart, and placenta. TRAP100 is characterized with a notional zinc finger at N-terminal, a putative ATP/GTP binding site in the central region, and six dispersed LXXLL motifs.
免疫原
The antiserum was produced against synthesized peptide derived from human MED24.
Immunogen Range: 801-850
Immunogen Range: 801-850
應用
Anti-MED24, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.
生化／生理作用
Mediator complex subunit 24 (MED24)/ thyroid hormone receptor associated protein 100 (TRAP100), which is a subunit of TRAP coactivator complex, might promote TRAP-mediated enhancement of nuclear receptor - signaling pathways. The MED1/MED24 complex plays an essential role in the pubertal mammary gland development and growth of breast carcinoma cells via the rat sarcoma (RAS)-mitogen-activated protein kinase (MAPK) pathway. The MED1/MED24 complex is over-expressed in female breast cancer (FBC). In Drosophila, mutation of gene encoding MED24 inhibit salivary gland cell death, caspase activation, and the breakdown of nuclear lamins.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Pascal Jézéquel et al.
Database : the journal of biological databases and curation, 2013, bas060-bas060 (2013-01-18)
We recently developed a user-friendly web-based application called bc-GenExMiner (http://bcgenex.centregauducheau.fr), which offered the possibility to evaluate prognostic informativity of genes in breast cancer by means of a 'prognostic module'. In this study, we develop a new module called 'correlation module'
Miangela M Lacle et al.
Cellular oncology (Dordrecht), 38(3), 237-245 (2015-04-24)
Overall, HER2-amplified female breast cancer (FBC) is associated with a high grade, an aggressive phenotype and a poor prognosis. In male breast cancer (MBC) amplification of HER2, located on chromosome 17, occurs at a lower frequency than in FBC, where
J Zhang et al.
Molecular endocrinology (Baltimore, Md.), 13(7), 1130-1140 (1999-07-16)
Nuclear hormone receptors (NRs) regulate transcription in part by recruiting distinct transcriptional coregulatory complexes to target gene promoters. The thyroid hormone receptor (TR) was recently purified from thyroid hormone-cultured HeLa cells in association with a complex of novel nuclear proteins
C X Yuan et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(14), 7939-7944 (1998-07-08)
Cognate cDNAs are described for 2 of the 10 thyroid hormone receptor-associated proteins (TRAPs) that are immunopurified with thyroid hormone receptor alpha (TRalpha) from ligand-treated HeLa (alpha-2) cells. Both TRAP220 and TRAP100 contain LXXLL domains found in other nuclear receptor-interacting
Lei Wang et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 239(3), 954-964 (2010-01-12)
The steroid hormone ecdysone triggers the rapid destruction of larval tissues through transcriptional cascades that culminate in rpr and hid expression and caspase activation. Here, we show that mutations in Mdh2 and Med24 block caspase cleavage and larval salivary gland
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