生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 74 kDa
种属反应性
rat, human, mouse
浓度
~1 mg/mL
技术
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... GAB2(9846)
一般描述
Anti-GAB2 Antibody detects endogenous levels of total GAB2 protein.
GAB2 (GRB2 associated binding protein 2), a mammalian homolog of GAB1 is a member of the family of insulin receptor substrate 1-like multi-substrate proteins. It is located on human chromosome 11q14.
免疫原
The antiserum was produced against synthesized peptide derived from human Gab2.
Immunogen Range: 125-174
Immunogen Range: 125-174
生化/生理作用
GAB2 (GRB2 associated binding protein 2) plays a major role in proliferation, survival and differentiation. It induces the multiplication of cells by initiating the extracellular signal-regulated kinase (ERK) signaling pathway in hepatocellular carcinoma.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection
Deng H, et al.
Frontiers in Cellular and Infection Microbiology (2017)
GAB2 promotes cell proliferation by activating the ERK signaling pathway in hepatocellular carcinoma
Chen Y, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(9), 11763-11773 (2016)
Eric M Reiman et al.
Neuron, 54(5), 713-720 (2007-06-08)
The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-nucleotide polymorphisms (SNPs) to characterize and confirm other LOAD susceptibility genes. In epsilon4 carriers from neuropathologically
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