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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 98 kDa
物種活性
rat, mouse, human
濃度
~1 mg/mL
技術
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PGR(5241)
一般說明
Anti-Progesterone receptor antibody detects endogenous levels of total progesterone receptor protein.
The progesterone receptor (PR) gene is mapped to human chromosome 11q22–23. The gene encodes for two isoforms, namely PR-A and PR-B, each of which is transcribed from a specific promoter region. The encoded receptor belongs to the family of steroid hormone receptors.
免疫原
The antiserum was produced against synthesized peptide derived from human Progesterone Receptor.
Immunogen Range: 261-310
Immunogen Range: 261-310
應用
Anti-Progesterone receptor antibody produced in rabbit has been used in western blotting and immunohistochemistry.
生化／生理作用
Progesterone receptor (PR) mediates the actions of progesterone which is essential to maintain pregnancy. PR is known to regulate the genes involved in the process of cell cycle, cell adhesion, invasion, differentiation, proliferation, inflammation, and apoptosis. PR expression might serve as a biomarker in axillary lymph node (ALN) metastasis. Abnormal expression of PR is observed in breast cancer.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Rapid impact of progesterone on the neuronal growth cone.
Olbrich L.
Endocrinology, 154(10), 3784-3795 (2013)
Absent progesterone receptor expression in the lymph node metastases of ER-positive, HER2-negative breast cancer is associated with relapse on tamoxifen.
Snell CE
Journal of Clinical Pathology, 70(11), 954-960 (2017)
CCAAT/enhancer binding protein ? negatively regulates progesterone receptor expression in human glioblastoma cells.
Hansberg-Pastor V
Molecular and Cellular Endocrinology, 439, 317-327 (2017)
No association between the progesterone receptor gene polymorphism (+331G/a) and the risk of breast cancer: an updated meta-analysis.
Qi XL
BMC Medical Genetics, 18(1):123, 1-7 (2017)
Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells.
Lee II
Oncogene, 35(39), 5191-5201 (2016)
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