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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 55 kDa
物種活性
human, mouse
濃度
~1 mg/mL
技術
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MDM2(4193)
一般說明
Anti-MDM2 antibody detects endogenous levels of total MDM2 protein.
Murine double minute 2 (MDM2) is an oncogenic protein. It is an E3 ubiquitin-protein ligase, that is mapped to human chromosome 12q15.
免疫原
The antiserum was produced against synthesized peptide derived from human MDM2.
Immunogen Range: 132-181
Immunogen Range: 132-181
應用
Anti-MDM2 antibody has been used in immunohistochemistry.
生化／生理作用
Murine double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor. It regulates cell cycle, cellular differentiation, cell fate determination, DNA repair and transcription. Epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells are induced by MDM2.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Angom Ranjana Devi et al.
Indian journal of clinical biochemistry : IJCB, 36(3), 296-303 (2021-07-06)
Nicotine, responsible for the addictive properties of tobacco, is widely used in nicotine replacement therapy for tobacco use cessation. We investigated the time-dependent effect of treatment with nicotine on the tumor suppressor, DNA repair and immune responses. Swiss Albino mice
MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells
Chen Y, et al.
British Journal of Cancer, 117(8), 1192-1192 (2017)
Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy
Zhou G, et al.
Investigative Ophthalmology & Visual Science, 58(12), 5361-5367 (2017)
HIV-1 Tat potently stabilises Mdm2 and enhances viral replication
Raja R, et al.
The Biochemical Journal (2017)
HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
Italiano A, et al.
International Journal of Cancer. Journal International Du Cancer, 122(10), 2233-2241 (2008)
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