生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
80 kDa
物種活性
human
濃度
1.0 mg/mL
技術
western blot: 1:500-1:1000 (Cell Lysate)
同型
IgG
登錄號
NP_002728.1.
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr657)
基因資訊
human ... PRKCA(5578)
一般說明
Protein kinase C α (PRKCA) is encoded by the gene mapped to human chromosome 17q24.2. The encoded protein is a member of the serine/threonine-specific protein kinase family.
特異性
The antibody detects endogenous levels of PKC α only when phosphorylated at tyrosine 658.
免疫原
Peptide sequence around phosphorylation site of tyrosine 658(F-S-Y(p)-V-N) derived from Human PKC α.
生化／生理作用
Protein kinase C α (PRKCA) is a serine-threonine kinase. It is associated with tumorigenesis, invasion, apoptosis, differentiation, angiogenesis and metastasis. Downregulation of PKCA inhibits the invasion of urinary bladder, colon, renal cell, breast carcinomas, multiple myeloma, glioma and endometrial cancer cells. In endothelial cells, PRKCA-mediated phosphorylation of TRPC1 (transient receptor potential cation channel subfamily C member 1) regulates store operated Ca2+ entry.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Identification of a Novel, Recurrent SLC44A1?PRKCA Fusion in Papillary Glioneuronal Tumor
Bridge JA, et al.
Brain Pathology, 23, 121-128 (2013)
Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo.
Wang A, et al.
Circulation Research, 90, 609-616 (2002)
Reduction of protein kinase C α (PKC-α) promote apoptosis via down-regulation of Dicer in bladder cancer.
Jiang Z, et al.
Journal of Cellular and Molecular Medicine, 19, 1085-1093 (2015)
PKC? promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness.
Vaskovicova K, et al.
BMC Cancer (2015)
Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.
Ahmmed GU, et al.
The Journal of Biological Chemistry, 279, 20941-20949 (2004)
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