生物源
rabbit
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
濃度
2.9 mg/mL
技術
immunohistochemistry: 1:25- 1:100
同型
IgG
登錄號
NP_004235.4
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CD163(9332)
一般說明
Cluster of differentiation 163 (CD163) is a hemoglobin scavenger receptor, encoded by a gene mapped to human chromosome 12p13.31. It is expressed on the surface of activated macrophages. The encoded protein is a member of scavenger receptor cysteine-rich family (SRCR) and is specifically expressed on cells of the monocyte/macrophage lineage.
特異性
The antibody detects endogenous levels of total CD163 protein.
免疫原
Synthetic peptide corresponding to residues near the C terminal of human CD163 molecule
生化／生理作用
Cluster of differentiation 163 (CD163) modulates anti-inflammatory functions and has a role in hemoglobin-haptoglobin clearance. Various cytokines influence the expression of CD163. It may be associated with hepatocellular carcinoma. Soluble CD163 level in serum acts as a potent indicator of the progression of cirrhosis and portal hypertension.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease.
Enomoto Y, et al.
Arthritis Research & Therapy, 19(1), 9-9 (2017)
SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis.
Constantine C C, et al.
BMC Medical Genetics, 9(1), 18-18 (2008)
Role of Serum Soluble CD163 in the Diagnosis, Risk of Bleeding, and Prognosis of Gastro-Esophageal Varices in Cirrhotic Patients.
Fouad R, et al.
Journal of Interferon & Cytokine Research, 37(3), 112-118 (2017)
Macrophage activation marker soluble CD163 may predict disease progression in hepatocellular carcinoma.
Kazankov K, et al.
Scandinavian Journal of Clinical and Laboratory Investigation, 76(1), 64-73 (2016)
C Buechler et al.
Journal of leukocyte biology, 67(1), 97-103 (2000-01-27)
CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among
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