SAB4300490
Anti-BRCA1 (Ab-1423) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-BRCAI antibody produced in rabbit, Anti-BRCC1 antibody produced in rabbit, Anti-IRIS antibody produced in rabbit, Anti-PSCP antibody produced in rabbit, Anti-breast cancer 1, early onset antibody produced in rabbit
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About This Item
推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~220 kDa
物種活性
human
濃度
1 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(H-G-S-Q-P)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... BRCA1(672)
一般說明
BRCA1 (breast cancer 1) is a tumor suppressor gene, that is located on human chromosome 17q21. It has an N-terminal RING (really interesting new gene) domain, a negatively charged region in its C terminus, and C-terminal sequences partially homologous to yeast RAD9.
免疫原
Peptide sequence around aa. 1421-1425 (H-G-S-Q-P), according to the protein BRCA1.
生化／生理作用
BRCA1 (breast cancer 1) mutation carriers are expected to get breast and ovarian cancer. It is involved in several cellular processes like transcription regulation, DNA damage repair and protein ubiquitination. Interaction of BRCA1 with PABP1 (poly(A)-binding protein 1) helps to control protein synthesis.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium
Easton DF, et al.
American Journal of Human Genetics, 56(1), 265-271 (1995)
BRCA1-Dependent Translational Regulation in Breast Cancer Cells
Dacheux E, et al.
PLoS ONE, 8(6) (2013)
Association of BRCA1 with Rad51 in mitotic and meiotic cells
Scully R, et al.
Cell, 88(2), 265-275 (1997)
Jing Yang et al.
International journal of biological sciences, 17(12), 3239-3254 (2021-08-24)
Breast cancer susceptibility gene 1 (BRCA1) encodes a tumor suppressor that is frequently mutated in familial breast and ovarian cancer patients. BRCA1 functions in multiple important cellular processes including DNA damage repair, cell cycle checkpoint activation, protein ubiquitination, chromatin remodeling
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