生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~43 kDa
物種活性
mouse, human
濃度
1 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(R-P-S-Y-R)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CREB1(1385)
一般說明
CREB1 (cAMP response element-binding protein) gene codes for a 43kDa cellular transcription factor, CREB. It has 341 amino acids. It belongs to the basic leucine zipper family of transcription factors. It is upregulated abundantly in human tissues and is located on chromosome 2q33–35.
免疫原
Peptide sequence around aa. 131-135 (R-P-S-Y-R), according to the protein CREB1.
生化／生理作用
Knockdown of CREB (cAMP response element-binding protein) blocks the development and promotes apoptosis in pre-B acute lymphoblastic leukemia cells by preventing prosurvival signals. It controls the transcription of antiapoptotic proteins in several cell types. Decrease in CREB phosphorylation leads to malfunction of mitochondria and hypoxia-induced apoptosis in chondrocytes.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Effects of the G(-656)A variant on CREB1 promoter activity in a neuronal cell line: interactions with gonadal steroids and stress
Zubenko GS and Hughes HB
Molecular Psychiatry (2009)
Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction
Qiu YY, et al.
Genetics and molecular research : GMR (2016)
Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection
Pregi N, et al.
Molecular and Cellular Biochemistry (2017)
CREB knockdown inhibits growth and induces apoptosis in human pre-B acute lymphoblastic leukemia cells through inhibition of prosurvival signals
Shabestari RM, et al.
Biomedicine and Pharmacotherapy (2017)
Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication In Vitro and Skin Pathogenesis In Vivo
Francois S, et al.
Journal of Virology (2016)
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