SAB4300226

Anti-phospho-SNCA (pTyr¹³³) antibody produced in rabbit

affinity isolated antibody

• 别名: Anti-MGC110988 antibody produced in rabbit, Anti-NACP antibody produced in rabbit, Anti-PARK1 antibody produced in rabbit, Anti-PARK4 antibody produced in rabbit, Anti-synuclein, alpha (non A4 component of amyloid precursor) antibody produced in rabbit
• MDL编号: MFCD02095740
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: ~18 kDa
• 种属反应性: human, rat, mouse
• 浓度: 1 mg/mL
• 技术: indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 同位素/亚型: IgG
• 免疫原序列: (E-G-YP-Q-D)
• NCBI登记号: NP_000336.1
• UniProt登记号: P37840
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: phosphorylation (pTyr133)
• 基因信息: human ... SNCA(6622)

说明

免疫原

Peptide sequence around phosphorylation site of tyrosine 133 (E-G-Y(p)-Q-D), according to the protein SNCA.

特点和优势

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目标描述

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable