生物来源
rabbit
偶联物
peroxidase conjugate
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
描述
Research area: Microbiome
表单
lyophilized powder
种属反应性
Pseudomonas aeruginosa
浓度
~4 mg/mL
技术
direct ELISA: 1:10,000-1:20,000 (is recommended using 1 μg/ml Pseudomonas Exotoxin A for coating.)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
Pseudomonas aeruginosa PAO1 ... toxA(877850)
一般描述
Pseudomonas aeruginosa is a Gram negative bacterium that rarely cause diseases in humans but certain populations, such as cystic fibrosis (CF) or burn wounds patients, are prone to such infections.
Pseudomonas Exotoxin A (PE) is the most potent virulence factor secreted by P. aeruginosa, it is composed of three structural domains, N-terminal domain (I) responsible for the toxin binding to its host cell receptor, middle domain (II) has a role in toxin translocation across the membrane, and C-terminal domain (III) has ADP-ribosylation activity. PE is considered as a selective agent for the elimination of specific cell populations due to its toxin ADP-ribosylation activity resulting in irreversibly shut down of protein synthesis. To reduce the adverse effects of natural PE, Mutated PE was used in several attempts to develop recombinant toxin-antibody or cytokines fusion fragments for therapeutic application including cancer immunotherapy.
Pseudomonas Exotoxin A (PE) is the most potent virulence factor secreted by P. aeruginosa, it is composed of three structural domains, N-terminal domain (I) responsible for the toxin binding to its host cell receptor, middle domain (II) has a role in toxin translocation across the membrane, and C-terminal domain (III) has ADP-ribosylation activity. PE is considered as a selective agent for the elimination of specific cell populations due to its toxin ADP-ribosylation activity resulting in irreversibly shut down of protein synthesis. To reduce the adverse effects of natural PE, Mutated PE was used in several attempts to develop recombinant toxin-antibody or cytokines fusion fragments for therapeutic application including cancer immunotherapy.
免疫原
Purified Exotoxin A from Pseudomonas aeruginosa
应用
The antibody may be used in various immunochemical techniques including ELISA.
外形
Supplied as a lyophilized powder.
其他说明
In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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