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生物源
rabbit
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
形狀
buffered aqueous solution
分子量
~100 kDa
物種活性
human
濃度
~1 mg/mL
技術
immunoblotting: 1-2 μg/mL using whole extracts of HEK-293T cells overexpressing human WHAMM.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... WHAMM(123720)
一般說明
WASP homologue associated with actin, membranes, and microtubules (WHAMM) is a nucleation promoting factor. It is located in the cis-Golgi and tubulo-vesicular membrane transport intermediates. WHAMM contains an N-terminal region, a coiled-coil region and a WCA region. It is located on the human chromosome at 15q25.2.
特異性
Anti- WHAMM (C-terminal) recognizes human WHAMM.
免疫原
peptide corresponding to the C-terminal region of human WHAMM , conjugated to KLH.
應用
Anti-WHAMM (C-terminal) produced in rabbit may be used in immunoblotting.
生化／生理作用
WASP homologue associated with actin, membranes, and microtubules (WHAMM) takes part in actin-related protein 2 & 3 (Arp2/3)-mediated actin polymerization, mediates Golgi membrane association and microtubule dynamics. It also takes part in the maintenance of Golgi structure and participates in vesicle transport between the endoplasmic reticulum and the Golgi apparatus.
外觀
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
儲存和穩定性
For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Seminars in cell & developmental biology
Seminars in Cell & Developmental Biology, 24(4), 258-266 (2013)
WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport.
Kenneth G Campellone et al.
Cell, 134(1), 148-161 (2008-07-11)
The Arp2/3 complex is an actin nucleator that plays a critical role in many cellular processes. Its activities are regulated by nucleation-promoting factors (NPFs) that function primarily during plasma membrane dynamics. Here we identify a mammalian NPF called WHAMM (WASP
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