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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~23 kDa
物種活性
human
濃度
~1.0 mg/mL
技術
immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded human heart
indirect immunofluorescence: 1-2 μg/mL using MCF7 cells
western blot: 1-2 μg/mL using extracts of OVCAR-3 cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CLDN5(7122)
一般說明
Claudin-5 (CLDN5) is encoded by the gene mapped to human chromosome 22q11.21. The encoded protein a 23kDa, four-transmembrane protein. It is mainly expressed in endothelial cells forming part of the blood-brain barrier (BBB).
免疫原
synthetic peptide corresponding to a sequence at the C-terminus of human claudin-5, conjugated to KLH. The corresponding sequence is highly conserved in mouse claudin-5 (single amino acid substitution) and in rat claudin-5 (89% identity).
應用
Anti-Claudin-5 (C-terminal) antibody has been used in I
- immunoblotting
- immunofluorescence
- immunohistochemistry
- immunolabelling
- immunocytochemistry
生化／生理作用
Claudin-5 (CLDN5), as an essential component of blood-brain barrier (BBB), plays a vital role in regulating the homeostasis of the central nervous system. Mutation in the gene increases the risk of susceptibility to schizophrenia. Overexpression of the gene is associated with the progression of pancreatic ductal adenocarcinomas. Loss of CLDN5 in cardiomyocytes and endothelial cells is one of the main reason behind human heart failure. Hence, early usage of CLDN5 can be considered as a potential therapeutic target for heart failure.
Claudin-5 has been shown to be overexpressed in various tumors including lung adenocarcinomas but undetectable in squamous cells cell carcinomas.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia
Greene C
Molecular Psychiatry (2017)
TP53 Mutation, Epithelial-Mesenchymal Transition, and Stemlike Features in Breast Cancer Subtypes
Coradini D
Journal of Biomedicine and Biotechnology (2012)
Molecular Architecture of the Blood Brain Barrier Tight Junction Proteins--A Synergistic Computational and In Vitro Approach.
Irudayanathan FJ
The Journal of Physical Chemistry B, 120, 77-88 (2016)
Expression of iron-related proteins at the neurovascular unit supports reduction and reoxidation of iron for transport through the blood-brain barrier
Burkhart A, et al.
Molecular Neurobiology, 53(10), 7237-7253 (2016)
Priscilla Ern Zhi Tan et al.
Experimental eye research, 172, 36-44 (2018-04-03)
We previously demonstrated endothelial phenotype heterogeneity in the vortex vein system. This study is to further determine whether regional differences are present in the cytoskeleton, junctional proteins and phosphorylated tyrosine labeling within the system. The vortex vein system of twenty
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