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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 225 kDa (rat)
antigen ~150 kDa (human)
物種活性
human, rat
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1.5 mg/mL
技術
western blot: 1-2 μg/mL using HEK-293T cells overexpressing human tensin1.
western blot: 1.5-3 μg/mL using lysates of A10 cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TNS1(7145)
mouse ... Tns1(21961)
rat ... Tns1(301509)
一般說明
Tensin 1, also known as TNS1, is a member of tensin protein family. Tensins are multi domain proteins containing homologous C1, protein phosphatases (PTPases), C2, Src homology 2 (SH2) domains and pTyr-binding (PTB) domains. Tensin 1 mRNA is widely expressed in mouse embryo and various human adult tissues and is localized to focal adhesions.
免疫原
synthetic peptide corresponding to a sequence located in the internal region of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.
應用
Anti-Tensin 1 (internal) antibody produced in rabbit has been used in immunoblotting.
生化／生理作用
Tensins play an important role in regulating cell shape and motility. Tensin 1 is involved in organizing the actin cytoskeleton and mediating signal transduction. TNS1 is implicated in myofibroblast differentiation. In addition, it also helps myofibroblasts to form nascent fibronectin and collagen matrix.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Tensin 1 is essential for myofibroblast differentiation and extracellular matrix formation
Bernau K, et al.
American Journal of Respiratory Cell and Molecular Biology, 56(4), 465-476 (2017)
Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration
Chen H, et al.
Proceedings of the National Academy of Sciences of the USA, 99(2), 733-738 (2002)
Individual domains of Tensin2 exhibit distinct subcellular localizations and migratory effects
Hafizi S, et al.
The International Journal of Biochemistry & Cell Biology, 42(1), 52-61 (2010)
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