生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
分子量
antigen ~160 kDa
种属反应性
human
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
浓度
~1.5 mg/mL
技术
western blot: 1.5-3.0 μg/mL using HEK-293T cells over expressing human tensin 2.
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TENC1(23371)
一般描述
Tensin 2 belongs to the Tensin family. It shares extensive homology with tensin1 at its N- and C-terminals, including the actin-binding domain, the Src Homology 2 (SH2) and c domains. Tensin 2 mRNA is highly expressed in heart, kidney, skeletal muscle and liver.
免疫原
synthetic peptide corresponding to a sequence located near the C-terminus human tensin 2 (GeneID: 23371), conjugated to KLH. The corresponding sequence is identical in human tensin 2 isoforms 2 and 3, and highly conserved (single amino acid substitution) in mouse tensin 2.
应用
Anti-Tensin 2 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.
生化/生理作用
Tensin 2 interacts with several binding partners through its Src Homology 2 (SH2)-phosphotyrosine binding (PTB) domains, including Axl receptor tyrosine kinase (RTK), caveolin-1 and with the tumor suppressor gene deleted in liver cancer 1 (DLC1) to regulate DLC1 tumor suppressor activity. Tensin 2 also inhibits Akt signaling and cell survival. It reduces intracellular PtdIns(3,4,5)P3 levels at the plasma membrane. It modulates cytoskeletal dynamics and impacts phosphoinositide-Akt signaling through its PTPase domain. Tensin 2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma (HCC).
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing
Marusugi K, et al.
The Journal of Veterinary Medical Science, 78(9), 1413-1420 (2016)
AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells
Cheng LC, et al.
Journal of Biomedical Science, 25(1), 80-80 (2018)
Kiyoma Marusugi et al.
The Journal of veterinary medical science, 78(9), 1413-1420 (2016-06-02)
Podocytes are terminally differentiated and highly specialized cells in the glomerulus, and they form a crucial component of the glomerular filtration barrier. The ICGN mouse is a model of glomerular dysfunction that shows gross morphological changes in the podocyte foot
Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function
Chan LK, et al.
PLoS ONE, 4(5), e5572-e5572 (2009)
Tensin2 reduces intracellular phosphatidylinositol 3, 4, 5-trisphosphate levels at the plasma membrane
Hafizi S, et al.
Biochemical and Biophysical Research Communications, 399(3), 396-401 (2010)
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