生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
分子量
18 kDa
种属反应性
mouse, human
浓度
1 mg/mL
技术
ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... VKORC1(79001)
一般描述
Vitamin K epoxide reductase complex subunit 1 (VKORC1), also known as vitamin K clotting factor deficiency type 2 (VKCFD2), is an integral, 163-amino acid long transmembrane protein. It is encoded by the gene mapped to a 20Mb region on human chromosome 16p12–q21. VKORC1 is widely expressed in various tissues and organs.
免疫原
Antibody was raised against a 15 amino acid peptide near the amino terminus of human VKORC1.
生化/生理作用
Vitamin K epoxide reductase complex subunit 1 (VKORC1) enzyme plays a vital role in vitamin K cycle. It catalyzes the conversion of inactive vitamin K to vitamin K hydroquinone, which is crucial for the post-translational γ-carboxylation of vitamin K–dependent clotting factors II (prothrombin), VII, IX, and X. VKORC1 acts as a key target for oral anticoagulants and is also involved in drug metabolism.{4} Genetic variation in the gene leads to warfarin resistance and multiple coagulation factor deficiency type 2.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500661.
外形
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
High prevalence of VKORC1*3 (G9041A) genetic polymorphism in north Indians: A study on patients with cardiac disorders on acenocoumarol.
Sehgal T
Drug Discoveries & Therapeutics (2015)
G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population.
Dubovyk YI
BioMed Research International (2016)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Rost S
Nature (2004)
VKCFD2 - from clinical phenotype to molecular mechanism.
Czogalla KJ
Hamostaseologie (2016)
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