生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
9H5A8, monoclonal
表单
buffered aqueous solution
种属反应性
mouse, human, rat
技术
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CD4(920)
一般描述
Cluster of differentiation (CD4) encodes a T-cell surface glycoprotein CD4. In human chromosome, the gene CD4 is localized on 12p13.31.
免疫原
raised against a 193 amino acid recombinant protein from near the amino terminus of human CD4.
生化/生理作用
Cluster of differentiation (CD4) mutation in single nucleotide causes OKT4 (Leu-3 T4) epitope deficiency. CD4 plays a major role in collateral artery formation by recruiting macrophages at the active site and through triggering the synthesis of arteriogenic cytokines.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.
外形
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
OKT4 epitope deficiency in patients infected with the human immunodeficiency virus: a cause of underestimation of the CD4 lymphocyte count
Khuong MA, et al.
Clinical Infectious Diseases, 19(5), 961-963 (1994)
Impaired Arteriogenic Response to Acute Hindlimb Ischemia in CD4-Knockout Mice
Stabile E, et al.
Cytokines, 108(5), 205-210 (2003)
Gene-expression profiling of titanium-cell interaction
Kim CS, et al.
The Journal of Korean Academy of Prosthodontics, 43(3), 393-408 (2005)
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