SAB1407028

Anti-ARID3B antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• 别名: BDP, DRIL2
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: mouse
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: purified immunoglobulin
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: antigen ~27.8 kDa
• 种属反应性: human
• 技术: indirect immunofluorescence: suitable; western blot: 1 μg/mL
• NCBI登记号: BC060824
• UniProt登记号: Q8IVW6
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... ARID3B(10620)

说明

一般描述

AT-rich interaction domain 3B (ARID3B) is encoded by the gene mapped to human chromosome 15q24.1. It is mainly expressed in leukocytes, placenta and testis. ARID3B belongs to the AT-rich interaction domain (ARID) family of proteins.

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. (provided by RefSeq)

免疫原

ARID3B (AAH60824.1, 1 a.a. ~ 253 a.a) full-length human protein.

Sequence
MEPLQQQQQQQQQQQKQPHLAPLQMDAREKQGQQMREAQFLYAQKLVTQPTLLSATAGRPSGSTPLGPLARVPPTAAVAQVFERGNMNSEPEEEDGGLEDEDGDDEVAEVAEKETQAASKYFHVQKVARQDPRVAPMSNLLPAPGLPPHGQQAKEDHTKDASKASPSVSTAGQPNWNLDEQLKQNGGLAWSDDADGGRGREISRDFAKLYELDGDPERKEFLDDLFVFMQKRGECASTHHSNSGNTDRVPTVC

生化/生理作用

AT-rich interaction domain 3B (ARID3B) plays a vital role in the survival of neural crest during embryogenesis. It is involved in the pathogenesis of malignant neuroblastoma. ARID3B also facilitates the expression of pro-apoptotic p53-target genes and apoptosis.

外形

Solution in phosphate buffered saline, pH 7.4

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable