推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~19.9 kDa
种属反应性
human
技术
western blot: 1 μg/mL
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GPLD1(2822)
一般描述
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. (provided by RefSeq)
免疫原
GPLD1 (AAH20748.1, 1 a.a. ~ 176 a.a) full-length human protein.
Sequence
MSAFRLWPGLLIMLGSLCHRGSPCGLSTHIEIGHRALEFLQLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLFGITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGTVYLHLLNFLVV
Sequence
MSAFRLWPGLLIMLGSLCHRGSPCGLSTHIEIGHRALEFLQLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLFGITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGTVYLHLLNFLVV
应用
Anti-GPLD1 antibody produced in mouse is suitable for western blot analysis.
生化/生理作用
GPLD1 (Glycosylphosphatidylinositol specific phospholipase D1) is only expressed in human lver. Inositol phosphate linkage in proteins anchored by phosphatidylinositol-glycans (PI-Gs) is specifically hydrolyzed by GPLD1, suggesting GPLD1 expression might influence the location and expression of PI-G-anchored proteins. Studies have reported that it might be a significant factor in process of leukemia pathogenesis.
外形
Solution in phosphate buffered saline, pH 7.4
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Guang-Fen Xiao et al.
Zhongguo shi yan xue ye xue za zhi, 18(1), 15-18 (2010-02-09)
This study was purposed to investigate the expression and significance of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in bone marrow mononuclear cells (BMMNC) isolated from patients with acute myeloid leukemia (AML), GPI-PLD activity in BMMNC isolated from 78 patients with AML and
Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D.
B J Scallon et al.
Science (New York, N.Y.), 252(5004), 446-448 (1991-04-19)
A phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) that specifically hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol-glycans (PI-Gs) has recently been purified from human and bovine sera. The primary structure of bovine PI-G PLD has now been determined and
J N Schofield et al.
Biochimica et biophysica acta, 1494(1-2), 189-194 (2000-11-10)
Here we report the structure of the human glycosylphosphatidylinositol phospholipase D1 gene, which covers at least 80 kb on chromosome 6p22. The gene comprises 25 exons and encodes a 5.8 kb mRNA, which was detected only in the liver. Southern
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